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Interspecies scaling (for example, body-surface-area conversion) typically reduces a rodent mg/kg figure severalfold, and even a properly scaled number would still be a hypothetical exposure , not a validated dose

135 Besides, Johnstone et al 174 found that the combined use of the chemotherapeutic drug ADM and multiple mammalian and plant-derived AMPs significantly increased the sensitivity of drug-resistant cells to ADM, thus improving the anti-tumor activity of ADM

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Pharmacopeia (USP) General Chapter 797, Pharmaceutical Compounding

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